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Fluorescent probes and functional materials for biomedical applications

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 10, Pages 1425-1437 doi: 10.1007/s11705-022-2163-1

Abstract: Due to their simplicity in preparation, sensitivity and selectivity, fluorescent probes have become the analytical tool of choice in a wide range of research and industrial fields, facilitating the rapid detection of chemical substances of interest as well as the study of important physiological and pathological processes at the cellular level. In addition, many long-wavelength fluorescent probes developed have also proven applicable for in vivo biomedical applications including fluorescence-guided disease diagnosis and theranostics (e.g., fluorogenic prodrugs). Impressive progresses have been made in the development of sensing agents and materials for the detection of ions, organic small molecules, and biomacromolecules including enzymes, DNAs/RNAs, lipids, and carbohydrates that play crucial roles in biological and disease-relevant events. Here, we highlight examples of fluorescent probes and functional materials for biological applications selected from the special issues “Fluorescent Probes” and “Molecular Sensors and Logic Gates” recently published in this journal, offering insights into the future development of powerful fluorescence-based chemical tools for basic biological studies and clinical translation.

Keywords： fluorescent probes imaging cell biomedicine biomolecules

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Base editors: development and applications in biomedicine

Frontiers of Medicine 2023, Volume 17, Issue 3, Pages 359-387 doi: 10.1007/s11684-023-1013-y

Abstract: Thus, base editors have important applications in the field of biomedicine, including gene function investigationscope, and capacity to be delivered in vivo, greatly enhancing their application potential in biomedicine

Keywords： base editing CBE ABE ADAR DdCBE disease model therapeutic application

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Preparation and application of magnetic microsphere carriers

ZHANG Bo, XING Jianmin, LIU Huizhou

Frontiers of Chemical Science and Engineering 2007, Volume 1, Issue 1, Pages 96-101 doi: 10.1007/s11705-007-0019-3

Abstract: have received considerable attention, primarily because of their wide applications in the fields of biomedicine

Keywords： microsphere biomedicine DNA purification preparation

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Digital Infrastructure System for Biomedical Research and Development

Zhang Jiannan,Wang Xiaojie,Sha Chulin,Li Yingying,Li Xiaokun,Tan Weihong,Li Lanjuan

Strategic Study of CAE 2023, Volume 25, Issue 5, Pages 92-102 doi: 10.15302/J-SSCAE-2023.05.018

Abstract:

The biomedical industry is developing at an unprecedented speed and the establishment and improvement of a digital infrastructure for biomedical research and development (R&D) is crucial for biotechnology innovation and Health China construction. This study analyzes the implication, classification, and systematic framework of the digital infrastructure for biomedical R&D in the new era. It summarizes the strategic layouts and development paths of the digital infrastructures for biomedical R&D in the United States, the European Union, and China, and examines the gap between China and European and American countries in terms of international influence and authority, development model design and efficiency, sustainability, and management organization construction. Moreover, it presents the challenges faced by the digital infrastructure of China regarding top-level design, management, and governance. Furthermore, we suggest that the following aspects should be strengthened: top-level framework design, coordination of biomedical and healthcare resources, clustered construction and governance of the platform, and capacity building and operationguarantee of the open platform.

Keywords： biomedicine digital infrastructure for research and development integrated platform data platform